Nyquole is not a popular first name for women and an equally uncommon surname or last name for both men and women. (1990 U.S. Census)
Nyquole \n(y)-quo-le\ as a girl's name is a variant of Nicole (Greek), and the meaning of Nyquole is "people of victory". The baby name Nyquole sounds like Nyquolle and Niquole. Other similar baby names are Nykole, Nycole, Nychole and Niquolle.